Medicinal Chemistry Services
We routinely apply computer sciences in computational chemistry approaches and apply methods for structure-based drug design, in case structural data of the target鈥�
High quality library design requires chemical creativity and profound synthesis knowledge to achieve the highest possible molecular diversity. Our efficient production鈥�
Looking for medicinal chemistry services for your drug discovery?
Comprehensive medicinal chemistry services
Our team knows how to rapidly uncover validated hits out of both random and focused screening efforts and we have a strong, documented track record in numerous pharmaceutical R&D hit-to-lead projects. We typically follow a multidimensional optimization (MDO) concept to avoid sequential testing and to address key issues in parallel and multi-objective screening cascades as early as possible, preventing optimization dead-ends and saving costs. Predefined criteria for meeting milestones and decision gates are typically agreed upon at the initiation of any project.
- 20 years of excellence in custom synthesis and medicinal chemistry research ensure molecules with optimised properties and patentability.
- Dedicated group for scaffold design and synthesis of compound libraries to gain quick access to a large number of compounds for SAR evaluation.
- Our proprietary project management software 糖果vlog官网网页版Gate庐 allows our scientists and clients to jointly analyse data and thereby provides support for informed selection of the next steps in the project.
- Our own multi-purpose pilot plant facility in Asia for large-scale syntheses grants us access to a broad supplier network for building blocks, etc.
Synthetic Organic Chemistry
Custom Synthesis
As a leading Contract Research Organization in Europe, 糖果vlog官网网页版 provides valuable contract discovery for synthetic organic chemistry, chemical process development, and鈥�
Therapeutic Areas
Indications and Gene Families
In Medicinal Chemistry research, we are working with a broadly experienced team on all biomolecular targets from any gene family in any therapeutic area鈥�
Looks interesting?
As a leading CRO in Europe, 糖果vlog官网网页版 provides comprehensive drug discovery chemistry services for large Pharma and Biotech corporations as well as for Research Institutes and Academia
Our experienced chemists practice a pragmatic culture and customer-centric approach in order to exceed project expectations and, despite challenges, bridge very narrow timelines. They are trained to consider economic, safety and ecological boundaries and conditions laid out for all stages of the project.
Frequently Asked Questions
What medicinal chemistry services does 糖果vlog官网网页版 provide?
糖果vlog官网网页版 provides medicinal chemistry support from hit validation and hit expansion through hit-to-lead, lead optimisation and candidate selection. Services include compound design and synthesis, structure-activity relationship exploration, scaffold modification, parallel synthesis, compound-library production and the optimisation of potency, selectivity, physicochemical properties, ADME behaviour and synthetic tractability.
How does 糖果vlog官网网页版 approach hit-to-lead and lead optimisation?
糖果vlog官网网页版 follows a multidimensional optimisation approach rather than optimising one property at a time. Potency, selectivity, solubility, permeability, metabolic stability, safety-related liabilities, intellectual-property position and synthetic accessibility can be evaluated in parallel. This helps identify optimisation conflicts earlier and reduces the risk of advancing a potent compound series that later fails because of another property.
How are computational chemistry and medicinal chemistry combined at 糖果vlog官网网页版?
糖果vlog官网网页版 combines medicinal chemistry with structure-based and ligand-based computational methods. Depending on the available data, the team may use virtual screening, molecular modelling, pharmacophore approaches, scaffold hopping, QSAR analysis and multiparameter design to prioritise compounds. Computational recommendations are evaluated alongside experimental synthesis, biological profiling and medicinal chemistry judgement.